NIH funds USC team to develop a selective Alzheimer's drug for APOE4 carriers
The team, led by Hussein Yassine of the Keck School of Medicine of USC, is investigating why some carriers of the APOE4 gene - the strongest ...
A new amyloid-lowering therapy is now available for people living with early Alzheimer's ...
... (APOE4) non-carriers or heterozygotes.1,2 Beta amyloid evidence consistent with Alzheimer's disease should be confirmed using a validated test ...
TGA approves registration of lecanemab (LEQEMBI)
... APOE4 gene), safety had not been satisfactorily established for patients who carry one copy of the APOE4 gene (APOE4 heterozygous carriers).
APOE4-APP interactions exert early influences on cerebrovascular structure and function ...
Background: APOE4 and APP are two of the main genetic risk factors for Alzheimer's disease (AD). Although there have been suggestions that these ...
Poor sleep may nudge the brain toward dementia, researchers find - Primedia Plus
Scientists suspect ApoE4 amplifies the damage of sleepless nights by slowing the overnight clearance of amyloid and making blood vessels more ...
Pluripotent Cells Expressing APOE4 Exhibit a Pronounced Pro-Apoptotic Phenotype ... - MDPI
MDPI ... APOE4 allele. In this study, we investigated the impact of APOE4 on NF-κB signaling in induced pluripotent stem (iPS) cells. Our results indicate ...
Rethinking Alzheimer's: Why this common gene variant is bad for your brain
The genetic variant APOE4, carried by one-fifth of the world's people, substantially boosts Alzheimer's risk. But scientists have been puzzled ...
This simple diet could help protect memory, even with Alzheimer's genes: Study - webindia123
People with two copies of the APOE4 variant (called APOE4 homozygous) have a 12-fold higher risk of Alzheimer's than those without. To explore how ...
APOE4 genotype and MAPT haplotype modify repetitive head impact biomarkers in retired ...
Here, we tested whether APOE4 and MAPT H1/H2 haplotypes function as genetic modifiers of biomarker trajectories in 111 retired professional fighters ...
Poor sleep may nudge the brain toward dementia, researchers find - Down To Earth
This increases the risk of cognitive decline, especially in individuals with the ApoE4 gene, a known risk factor for Alzheimer's. Staring at the ...
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases | Nature Metabolism
A common variant in ApoE, ApoE4, is the major genetic risk factor for AD, which increases the risk for AD from 3–4-fold (heterozygosity) to 14-fold ( ...
Scientists find physical exercise can reduce risk of developing dementia - ABC News
ApoE4 is the strongest genetic risk factor for Alzheimer's disease and dementia. What is the ApoE4 gene that Chris Hemsworth has?
Microplastics Linked to Worsening Alzheimer's Symptoms in Mice - ScienceAlert
... APOE4 that consumed microplastics did begin showing signs of cognitive decline. Mice with the APOE3 gene, and APOE4 mice that hadn't been exposed ...
Microplastics from takeaway boxes may be fuelling Alzheimer's, study says - Daily Record
The research involved examining mice that had been genetically modified to include the naturally occurring gene APOE4- a gene often associated with a ...
Microplastics may worsen memory, thinking problems in Alzheimer's risk mice - NewsBytes
... (APOE4). Mice without this gene, or those not exposed to microplastics, didn't show these issues. Male mice show apathy, females have memory issues.
Plastic Particles In Food May Raise Alzheimer's Risk, Study Finds - Menafn.com
... APOE4 gene, a genetic variant linked to a higher likelihood of developing the disease. A Gene–Environment Interaction. To test the impact, Ross and ...
High-Impact Pain Predicts Subjective Cognitive Decline and Interacts with APOE4 Genotype ...
High-impact pain also predicted an increased risk of objective cognitive impairment, particularly in individuals without the APOE4 allele. The ...
High-Impact Pain Predicts Subjective Cognitive Decline and Interacts with APOE4 Genotype ...
The aHR for objective cognitive impairment compared to no or low-impact pain was 1.21 (95% CI: 1.07, 1.36) in APOE4-negative individuals, controlling ...
Coconut oil's role in Alzheimer's and depression - KevinMD.com
The APOE4 variant is associated with an increased risk of Alzheimer's disease and cardiovascular issues. Depression. In 2023, Chinese researchers ...
Apolipoprotein E Alleles and Motor Signs in Older Adults with Alzheimer's Dementia
APOE4 may have a protective effect. Keywords: Alzheimer's dementia; apolipoprotein E; bradykinesia; gait; motor signs; posture; rigidity; tremor.